https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Neural control of the bronchial circulation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1396 Sat 24 Mar 2018 08:28:01 AEDT ]]> Dynamic range of evoked cholinergic and non-cholinergic non-adrenergic vasodilatation in bronchoesphageal circulation in the awake dog https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12782 Sat 24 Mar 2018 08:17:34 AEDT ]]> Dynamic control of the bronchial circulation in the conscious dog: preliminary data on the role of alpha and beta adrenoceptors, and of cholinoceptors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12747 Sat 24 Mar 2018 08:16:36 AEDT ]]> Integration of baroreflex and autoregulation control of bronchial blood flow in awake dogs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11792 Q = 0.034 + 0.00033(X_Pg − 104.6). The regression fell on the line of equal proportional change. Conclusion: Baroreflexes do not functionally engage the autonomic outflow to the bronchial circulation. Under controlled conditions of systemic Pg change, the bronchial circulation is normally controlled by the integration of resting autonomic tone, myogenic autoregulation and pressure-passive effects.]]> Sat 24 Mar 2018 08:10:21 AEDT ]]> Differential effects of inhaled methacholine on circumferential wall and vascular smooth muscle of third-generation airways in awake sheep https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12405 br), Q_br conductance (C_br), bronchial hemicircumference (CIRC_br), and bronchial wall thickness (WALL TH_br) in recovered, standing, awake sheep. Methacholine (MCh; 0.125–2.0 μg/kg iv), at the highest dose, caused a 233% rise in Qbr (P < 0.05) and a 286% rise in C_br (P < 0.05). CIRC_br fell to 90% (P < 0.05); WALL TH_br did not change. In contrast, nebulized MCh (1–32 mg/ml), inhaled through a mask at the highest dose, caused a rise in ventilation and a rise in Qbr proportional to aortic pressure without change in C_br. CIRC_br fell to 91% (P < 0.01), and WALL TH_br did not change. Thus inhaled MCh has access to cholinoceptors of bronchial circumferential smooth muscle to cause airway lumen narrowing but effectively not to those of the systemic bronchovascular circulation. It is speculated that the mechanism is selective neuroparacrine inhibition of muscarinic acetylcholine receptors (M3 bronchovascular cholinoceptors) by prostanoids released by intense MCh activation of epithelial and mucosal cells lining the airway.]]> Fri 27 Sep 2019 16:25:54 AEST ]]>